Clarendon Hills Middle School opened August 28, 2000, the first new school in District 181 in 24 years. It was dedicated on September 24, 2000.
The new school's Parent Teacher Organization completed an engraved brick walkway surrounding the flagpole in front of the school as its first fundraising project.
Walter A. Kistenfeger, Jr. served as the school's first principal, having previously led Hinsdale Middle School. The construction was funded by passage of a $12.8 million referendum in November 1997. Previous referenda to replace Hinsdale Middle School on the Hinsdale site failed in March and November 1996.
In the 2000-01 school year, the 88,268 square foot building had an enrollment of 611 students. These students came to the new school from the Prospect, Walker, Monroe and the Lane attendance areas. Enrollment grew steadily to 818 students in September 2007. The Board of Education approved a realignment of feeder schools in early 2008. At the beginning of the 2008 - 09 school year, sixth-grade students from The Lane School attendance area began attending Hinsdale Middle School.
The school's traditional architecture reflects community input, gathered in a public process prior to the buildings design by STR Partners, Ltd. Extensive intergovernmental agreements with the Village of Clarendon Hills and the Clarendon Hills Park District took place prior to construction on property previously owned by the park district. As a result of the intergovernmental agreements, District 181 included a multi-purpose room and offices for the park district at the west end of the building.